RNA methylation in nuclear pre-mRNA processing
نویسندگان
چکیده
منابع مشابه
The burden of history: nuclear pre-mRNA processing imprints mRNAs
Introduction mRNA turnover plays an important role in the regulation of gene expression, affecting both the total amount of protein that can be synthesized from a given level of transcription and the time that translation continues. It has long been appreciated that the structure of the messenger ribonucleoprotein particle (mRNP) complex is likely to play an important role in both translation a...
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In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, after the discovery of self-splicing group II intron RNAs, the snRNAswere proposed to catalyse splicing. However, no definitive evidence for a role of either RNAor protein in catalysis by the spliceosome has been repor...
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Multiple members of the ADAR (adenosine deaminases acting on RNA) gene family are involved in A-to-I RNA editing. It has been speculated that they may form a large multicomponent protein complex. Possible candidates for such complexes are large nuclear ribonucleoprotein (lnRNP) particles. The lnRNP particles consist mainly of four spliceosomal subunits that assemble together with the pre-mRNA t...
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Cytosine DNA methylation is a stable epigenetic mark that is frequently associated with the silencing of genes and transposable elements (TEs). In Arabidopsis, the establishment of DNA methylation is through the RNA-directed DNA methylation (RdDM) pathway. Here, we report the identification and characterization of RDM16, a new factor in the RdDM pathway. Mutation of RDM16 reduced the DNA methyl...
متن کاملRNA transcription and mRNA processing
Category: Molecular genetics Significance: Translation of messenger RNA molecules (mRNAs) occurs even while transcription is taking place in prokaryotes. In eukaryotes the process is much more complex, with transcription occurring in the nucleus, followed by multiple processing steps before a mature mRNA is ready to be translated. All of these extra steps are required for mRNAs to be transporte...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: RNA
سال: 2018
ISSN: 1757-7004
DOI: 10.1002/wrna.1489